Endothelial dysfunction in hypertension: current concepts and clinical implications
Endothelium plays a fundamental role in the cardiovascular system, forming an interface
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …
Blood-brain barrier damage in ischemic stroke and its regulation by endothelial mechanotransduction
Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …
METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium
Atherosclerosis is characterized by the plaque formation that restricts intraarterial blood flow.
The disturbed blood flow with the associated oscillatory stress (OS) at the arterial curvatures …
The disturbed blood flow with the associated oscillatory stress (OS) at the arterial curvatures …
Rapid regeneration of a neoartery with elastic lamellae
Native arteries contain a distinctive intima‐media composed of organized elastin and an
adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small …
adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small …
Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction
C Xue, K Chen, Z Gao, T Bao, LS Dong, L Zhao… - Cell Communication and …, 2023 - Springer
Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …
Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases
V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …
Insulin resistance and hypertension: Mechanisms involved and modifying factors for effective glucose control
HF Sakr, SR Sirasanagandla, S Das, AI Bima… - Biomedicines, 2023 - mdpi.com
Factors such as aging, an unhealthy lifestyle with decreased physical activity, snacking, a
standard Western diet, and smoking contribute to raising blood pressure to a dangerous …
standard Western diet, and smoking contribute to raising blood pressure to a dangerous …
Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders
Red blood cell (RBC) disorders such as sickle cell disease affect billions worldwide. While
much attention focuses on altered properties of aberrant RBCs and corresponding …
much attention focuses on altered properties of aberrant RBCs and corresponding …
The endothelium as a therapeutic target in diabetes: a narrative review and perspective
Diabetes has reached worldwide epidemic proportions, and threatens to be a significant
economic burden to both patients and healthcare systems, and an important driver of …
economic burden to both patients and healthcare systems, and an important driver of …
Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput
A Nguyen, M Brandt, TM Muenker, T Betz - Lab on a Chip, 2021 - pubs.rsc.org
Active microrheology is one of the main methods to determine the mechanical properties of
cells and tissue, and the modelling of these viscoelastic properties is under heavy debate …
cells and tissue, and the modelling of these viscoelastic properties is under heavy debate …