Endothelial dysfunction in hypertension: current concepts and clinical implications

G Gallo, M Volpe, C Savoia - Frontiers in medicine, 2022 - frontiersin.org
Endothelium plays a fundamental role in the cardiovascular system, forming an interface
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …

Blood-brain barrier damage in ischemic stroke and its regulation by endothelial mechanotransduction

K Nian, IC Harding, IM Herman, EE Ebong - Frontiers in physiology, 2020 - frontiersin.org
Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …

METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium

CS Chien, JYS Li, Y Chien, ML Wang… - Proceedings of the …, 2021 - National Acad Sciences
Atherosclerosis is characterized by the plaque formation that restricts intraarterial blood flow.
The disturbed blood flow with the associated oscillatory stress (OS) at the arterial curvatures …

Rapid regeneration of a neoartery with elastic lamellae

Z Wang, SM Mithieux, H Vindin, Y Wang… - Advanced …, 2022 - Wiley Online Library
Native arteries contain a distinctive intima‐media composed of organized elastin and an
adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small …

Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction

C Xue, K Chen, Z Gao, T Bao, LS Dong, L Zhao… - Cell Communication and …, 2023 - Springer
Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

Insulin resistance and hypertension: Mechanisms involved and modifying factors for effective glucose control

HF Sakr, SR Sirasanagandla, S Das, AI Bima… - Biomedicines, 2023 - mdpi.com
Factors such as aging, an unhealthy lifestyle with decreased physical activity, snacking, a
standard Western diet, and smoking contribute to raising blood pressure to a dangerous …

Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders

X Cheng, C Caruso, WA Lam, MD Graham - Science advances, 2023 - science.org
Red blood cell (RBC) disorders such as sickle cell disease affect billions worldwide. While
much attention focuses on altered properties of aberrant RBCs and corresponding …

The endothelium as a therapeutic target in diabetes: a narrative review and perspective

JA Adams, A Uryash, JR Lopez, MA Sackner - Frontiers in physiology, 2021 - frontiersin.org
Diabetes has reached worldwide epidemic proportions, and threatens to be a significant
economic burden to both patients and healthcare systems, and an important driver of …

Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput

A Nguyen, M Brandt, TM Muenker, T Betz - Lab on a Chip, 2021 - pubs.rsc.org
Active microrheology is one of the main methods to determine the mechanical properties of
cells and tissue, and the modelling of these viscoelastic properties is under heavy debate …