Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for
Predictive Toxicology | Chemical Reviews ACS ACS Publications C&EN CAS Find my …

There is an increasing interest in predicting the toxicological effects of chemicals from their
structure and physicochemical properties. For new compounds, this will optimize the product …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

The application of gene expression profiling technology to examine multiple genes and
signaling pathways simultaneously promises a significant advance in understanding toxic …

Peroxisome proliferators are a diverse group of chemicals that include several
therapeutically used drugs (eg, hypolipidemic agents), plasticizers and organic solvents …

Dichlorodiphenyltrichloroethane (DDT) is still used in certain areas of tropics and subtropics
to control malaria and other insect-transmitted diseases. DDT and its metabolites have been …

Entering a new millennium seems a good time to challenge some old ideas, which in our
view are implausible, have little supportive evidence, and might best be left behind. In this …

Recent regulatory guidance for mixture risk assessments and for regulating pesticide
chemicals recommends using information about the “mode” or “mechanism” of action of …

The major causes of cancer are: 1) smoking, which accounts for about a third of US cancer
and 90% of lung cancer; 2) dietary imbalances: lack of sufficient amounts of dietary fruits and …

In recent years, several regulatory agencies and professional societies have recommended
an occupational exposure limit (OEL) for formaldehyde. This article presents the findings of a …