This review draws on data obtained in the cancer pain, nonmalignant pain, and addict
populations to examine critically the major issues raised by the use of chronic opioid therapy …

Opioids have been endorsed as appropriate treatment for refractory chronic non-cancer pain
when used according to published guidelines. They are widely used for this indication …

'The Globalization of Addiction'presents a radical rethink about the nature of addiction.
Scientific medicine has failed when it comes to addiction. There are no reliable methods to …

Aims Our study sought to assess the prevalence of and risk factors for opioid drug
dependence among out‐patients on long‐term opioid therapy in a large health‐care system …

Objectives: To compare patients' preference for transdermal fentanyl or sustained release
oral morphine, their level of pain control, and their quality of life after treatment. Design …

Adverse effects of opioids are multiple. They are most often receptor-mediated and
inseparable from their desired effects. The most severe mishaps with opioids are related to …

Background: Buprenorphine is a potent opioid analgesic that is available in sublingual and
parenteral formulations. A new formulation, buprenorphine transdermal delivery system …

Physicians involved in cancer pain management treat thousands of patients with opioids,
whose effective analgesia improves overall functioning. Side effects generally are tolerable …

The analgesic efficacy and tolerability of lornoxicam (Xefo [registered sign]; Nycomed
Pharma A/S, Roskilde, Denmark), a new nonsteroidal antiinflammatory drug, was compared …

Medical practice with respect to the use of opioids for the treatment of pain has been heavily
influenced by societal perceptions of problems of addiction and by laws governing the use of …