Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels
of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There …

Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

Rationale One of the major complaints most people face during aging is an impairment in
cognitive functioning. This has a negative impact on the quality of daily life and is even more …

Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40
isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic …

Aims Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-
promoting reduction of L-type Ca2+-current (ICa, L), the mechanisms of which are poorly …

Thyroid-stimulating hormone (TSH) controls thyroid growth and hormone secretion through
binding to its G protein-coupled receptor (TSHR) and production of cyclic AMP (cAMP) …

Introduction: PDEs are key enzymes in the adenosine and guanosine cyclic nucleotides
(cAMP and cGMP) signaling cascade. Their inhibition increases cyclic nucleotide levels …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …