Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Research using animal model systems has been instrumental in delivering improved
therapies for breast cancer, as well as in generating new insights into the mechanisms that …

High lethality rates associated with metastatic cancer highlight an urgent medical need for
improved understanding of biologic mechanisms driving metastatic spread and identification …

Simple Summary In cancer, disseminated neoplastic cells circulating in blood are a source
of tumor DNA, RNA, and protein, which can be harnessed to diagnose, monitor, and better …

The same gene can have many different functions in different places in the body and/or at
different times in development and adult life. Often only one organ or one developmental …

Cellular fusion eg between cancer cells and normal cells represents a stepwise process that
is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer …

Simple Summary Cell fusion as a fundamental biological process is required for various
physiological processes, including fertilization, placentation, myogenesis …

Current strategies to determine tumor× normal (TN)-hybrid cells among human cancer cells
include the detection of hematopoietic markers and other mesodermal markers on tumor …

Simple Summary Aberrant fusion of somatic cells or fusion of neoplastic cells may represent
one fundamental process among others eventually promoting tumor development. Fusion …

The phenomenon of cancer cell–cell fusion is commonly associated with the origin of more
malignant tumor cells exhibiting novel properties, such as increased drug resistance or an …