DNA methylation: a mechanism for embedding early life experiences in the genome

M Szyf, J Bick - Child development, 2013 - Wiley Online Library
Although epidemiological data provide evidence that early life experience plays a critical
role in human development, the mechanism of how this works remains in question. Recent …

The social environment and the epigenome

M Szyf, P McGowan, MJ Meaney - … and molecular mutagenesis, 2008 - Wiley Online Library
The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

Epigenetics, DNA methylation, and chromatin modifying drugs

M Szyf - Annual review of pharmacology and toxicology, 2009 - annualreviews.org
Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

The epigenetics of social adversity in early life: implications for mental health outcomes

PO McGowan, M Szyf - Neurobiology of disease, 2010 - Elsevier
An organism's behavioral and physiological and social milieu influence and are influenced
by the epigenome, which is composed predominantly of chromatin and the covalent …

Oligomeric compounds and compositions for use in modulation of small non-coding RNAs

C Esau, B Lollo, CF Bennett, SM Freier… - US Patent …, 2010 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
34139820&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

The early life environment and the epigenome

M Szyf - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
Several lines of evidence point to the early origin of adult onset disease. A key question is:
what are the mechanisms that mediate the effects of the early environment on our health …

Computational prediction of miRNAs in Arabidopsis thaliana

A Adai, C Johnson, S Mlotshwa… - Genome …, 2005 - genome.cshlp.org
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in animals and
plants. Comparative genomic computational methods have been developed to predict new …

Epigenetic mechanisms in anti‐cancer actions of bioactive food components–the implications in cancer prevention

B Stefanska, H Karlic, F Varga… - British journal of …, 2012 - Wiley Online Library
The hallmarks of carcinogenesis are aberrations in gene expression and protein function
caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in …

Maternal care, the epigenome and phenotypic differences in behavior

M Szyf, I Weaver, M Meaney - Reproductive toxicology, 2007 - Elsevier
The genome is programmed by the epigenome, which is comprised of chromatin and a
covalent modification of DNA by methylation. Epigenetic patterns are sculpted during …

Diet and the epigenetic (re) programming of phenotypic differences in behavior

PO McGowan, MJ Meaney, M Szyf - Brain research, 2008 - Elsevier
Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program
tissue specific patterns of gene expression. Cells, including neurons, undergo massive …