Considering Caenorhabditis elegans Aging on a Temporal and Tissue Scale: The Case of Insulin/IGF-1 Signaling
P Fabrizio, A Alcolei, F Solari - Cells, 2024 - mdpi.com
The aging process is inherently complex, involving multiple mechanisms that interact at
different biological scales. The nematode Caenorhabditis elegans is a simple model …
different biological scales. The nematode Caenorhabditis elegans is a simple model …
Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast
BL Mariner, DP Felker, RJ Cantergiani… - International Journal of …, 2023 - mdpi.com
We have shown that multiple tRNA synthetase inhibitors can increase lifespan in both the
nematode C. elegans and the budding yeast S. cerevisiae by acting through the conserved …
nematode C. elegans and the budding yeast S. cerevisiae by acting through the conserved …
Microsporidia: Pervasive natural pathogens of Caenorhabditis elegans and related nematodes
The nematode Caenorhabditis elegans is an invaluable host model for studying infections
caused by various pathogens, including microsporidia. Microsporidia represent the first …
caused by various pathogens, including microsporidia. Microsporidia represent the first …
[HTML][HTML] CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance
MB Sarmiento, SS Gang, P van Oosten-Hawle… - Cell Reports, 2024 - cell.com
Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin
ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular …
ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular …
Age‐dependent heat shock hormesis to HSF‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in …
The transcription factor HSF‐1 (heat shock factor 1) acts as a master regulator of heat shock
response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective …
response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective …