The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

DP Veitch, MW Weiner, M Miller, PS Aisen… - Alzheimer's & …, 2024 - Wiley Online Library
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve
Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging …

Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis

A Seyedsalehi, V Warrier, RAI Bethlehem, BI Perry… - Brain, 2023 - academic.oup.com
Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health

RN Kalaria, RO Akinyemi, SM Paddick… - Expert Review of …, 2024 - Taylor & Francis
Introduction The true global burden of vascular cognitive impairment (VCI) is unknown.
Reducing risk factors for stroke and cardiovascular disease would inevitably curtail VCI …

Exposure to coal dust exacerbates cognitive impairment by activating the IL6/ERK1/2/SP1 signaling pathway

F Cai, S Xue, Z Zhou, X Zhang, Y Kang, J Zhang… - Science of The Total …, 2024 - Elsevier
Coal dust (CD) is a common pollutant, and epidemiological surveys indicate that long-term
exposure to coal dust not only leads to the occurrence of pulmonary diseases but also has …

Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age

S He, Y Guan, CH Cheng, TL Moore… - Frontiers in Aging …, 2023 - frontiersin.org
The application of artificial intelligence (AI) to summarize a whole-brain magnetic resonance
image (MRI) into an effective “brain age” metric can provide a holistic, individualized, and …

APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts

Y Guan, CH Cheng, LI Bellomo, S Narain… - Frontiers in Aging …, 2023 - frontiersin.org
Background Apolipoprotein E (APOE) is the strongest genetic risk factor for sporadic
Alzheimer's Disease (AD), and the ε4 allele (APOE4) may interact with lifestyle factors that …

Changes in myelinated fibers in the hippocampus of streptozotocin-induced diabetic rats: a stereological investigation

H Zhao, T Zhang, F Zhao, M Tan, S Du… - Folia …, 2024 - journals.viamedica.pl
Diabetes causes cognitive impairment, and the hippocampus is important for long-term and
permanent memory function. However, the mechanism of their interaction is still unclear. In …

[HTML][HTML] Metabolites and MRI-Derived Markers of AD/ADRD Risk in a Puerto Rican Cohort

S Gordon, JS Lee, TM Scott, S Bhupathiraju… - Research …, 2024 - ncbi.nlm.nih.gov
Objective Several studies have examined metabolomic profiles in relation to Alzheimer's
disease and related dementia (AD/ADRD) risk; however, few studies have focused on …

Acculturation in Context: A Framework for Investigating Cognitive and Brain Aging in People of Hispanic and Latin American Descent

M Lamar, LL Barnes, DX Marquez - Older Mexicans and Latinos in the …, 2024 - Springer
Abstract People of Hispanic and Latin American descent are one of the fastest growing
minoritized populations in the US, and they are approximately 1.5 times as likely to develop …

[HTML][HTML] 2 型糖尿病认知功能障碍影响因素的研究进展

刘敏丽, 韩继明, 呼敏, 王治国, 边红艳 - Advances in Clinical …, 2023 - hanspub.org
随着生活水平提高和人口老龄化进程加速, 2 型糖尿病患病率日益增高. 认知功能障碍是2
型糖尿病的慢性并发症, 导致患者的记忆力, 理解力下降, 空间定位障碍, 严重影响患者的自理 …