Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

An essential prerequisite for the survival of an organism is the ability to detect and respond
to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory …

The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …