Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living
organisms and is denoted as a persistent condition of an imbalance between the generation …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a
maximum lifespan exceeding 30 years,,. This is the longest reported lifespan for a rodent …

Multicellularity is characterized by cooperation among cells for the development,
maintenance and reproduction of the multicellular organism. Cancer can be viewed as …

The ongoing West African Ebola epidemic highlights a recurring trend in the zoonotic
emergence of virulent pathogens likely to come from bat reservoirs that has caused …