The establishment of rules that link sequence and amyloid feature is critical for our
understanding of misfolding diseases. To this end, we have performed a saturation …

Study of the hierarchy of domain structure with alternative sets of domains and analysis of
discontinuous domains, consisting of remote segments of the polypeptide chain, raised a …

Reconstruction of the earliest proteins in the ancient binary alphabet [glycine family G,
alanine family A] leads to repeats of G alternating with repeats of A. In addition, omnipresent …

Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme
environmental conditions, it is possible to explore the genomic-proteomic compositional …

Hand-in-hand work of physics and evolution delivered protein universe with diversity of
forms, sizes, and functions. Pervasiveness and advantageous traits of allostery made it an …

Background Extant life depends greatly on the binding of small molecules (such as ligands)
with macromolecules (such as proteins), and one ligand can bind multiple proteins …

A simple two-state model for the dependence of the rate of folding of a polypeptide confined
within a spherical cavity upon the size of the cavity relative to that of the polypeptide is …

Background Manually finding subtle yet statistically significant links to distantly related
homologues becomes practically impossible for very populated protein families due to the …

Binding of nucleotides and their derivatives is one of the most ancient elementary functions
dating back to the Origin of Life. We review here the works considering one of the key …

Motivation: Enzymes are complex catalytic machines, which perform sequences of
elementary chemical transformations resulting in biochemical function. The building blocks …