3D cell culture methods confer a high degree of clinical and biological relevance to in vitro
models. This is specifically the case with the spheroid culture, where a small aggregate of …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Conventional 3D printing may not readily incorporate bioactive ingredients for controlled
release because the process often involves the use of heat, organic solvent, or crosslinkers …

Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into
many cell types. Chondrogenesis is induced in hMSCs cultured as a micromass pellet to …

Many biochemical factors regulating progenitor cell differentiation have been examined in
detail; however, the role of the local mechanical environment on stem cell fate has only …

The extracellular matrix (ECM) is an intricate network of proteins that surrounds cells and
has a central role in establishing an environment that is conducive to tissue-specific cell …

It is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is
regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in …

Accumulating evidence suggests that the mechanical and biochemical signals originating
from cell–cell adhesion are critical for stem cell lineage specification. In this review, we focus …

Cell behaviours within tissues are influenced by a broad array of physical and biochemical
microenvironmental factors. Whilst 'stiffness' is a recognised physical property of substrates …

N-cadherin, a transmembrane protein and major component of adherens junction, mediates
cell-cell interactions and intracellular signaling that are important to the regulation of cell …