Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia

J Voelkl, F Lang, KU Eckardt, K Amann… - Cellular and Molecular …, 2019 - Springer
Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Magnesium and hypertension in old age

LJ Dominguez, N Veronese, M Barbagallo - Nutrients, 2020 - mdpi.com
Hypertension is a complex condition in which various actors and mechanisms combine,
resulting in cardiovascular and cerebrovascular complications that today represent the most …

[HTML][HTML] WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression

T Cai, D Sun, Y Duan, P Wen, C Dai, J Yang… - Experimental cell …, 2016 - Elsevier
Arterial medial calcification (AMC) is prevalent in patients with chronic kidney disease (CKD)
and contributes to elevated risk of cardiovascular events and mortality. Vascular smooth …

A randomized trial of magnesium oxide and oral carbon adsorbent for coronary artery calcification in predialysis CKD

Y Sakaguchi, T Hamano, Y Obi, C Monden… - Journal of the …, 2019 - journals.lww.com
Background Developing strategies for managing coronary artery calcification (CAC) in
patients with CKD is an important clinical challenge. Experimental studies have …

Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis

S O'Grady, MP Morgan - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
The implementation of mammographic screening programmes in many countries has been
linked to a marked increase in early detection and improved prognosis for breast cancer …

Biodegradable Mg-based alloys: biological implications and restorative opportunities

X Lin, Saijilafu, X Wu, K Wu, J Chen, L Tan… - International …, 2023 - Taylor & Francis
Mg-based alloys as revolutionary implantable biomaterials have increasingly attracted
considerable attention, owing to their biodegradability in vivo and beneficial effects on …

Osteocalcin regulates arterial calcification via altered Wnt signaling and glucose metabolism

NA Rashdan, AM Sim, L Cui, K Phadwal… - Journal of Bone and …, 2020 - academic.oup.com
Arterial calcification is an important hallmark of cardiovascular disease and shares many
similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an …

Insights into the role of magnesium ions in affecting osteogenic differentiation of mesenchymal stem cells

T Qi, J Weng, F Yu, W Zhang, G Li, H Qin, Z Tan… - Biological trace element …, 2021 - Springer
Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to
differentiate into bone-producing cells, which is essential for bone formation. Magnesium …

Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation

AD Ter Braake, PT Tinnemans, CM Shanahan… - Scientific reports, 2018 - nature.com
Magnesium has been shown to effectively prevent vascular calcification associated with
chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of …