The unraveling of the regulatory mechanisms that govern neuronal excitability is a major
challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining …

Dopamine regulates emotional behaviors, including rewarding and aversive behaviors,
through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the …

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders.
Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium …

The N-methyl-D-aspartate receptor (NMDAR)-mediated structural plasticity of dendritic
spines plays an important role in synaptic transmission in the brain during learning and …

Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning
from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca2+ …

The structural plasticity of dendritic spines plays a critical role in NMDA-induced long-term
potentiation (LTP) in the brain. The small GTPases RhoA and Ras are considered key …

Introduction Since the emergence of the cholinergic hypothesis of Alzheimer's disease (AD),
acetylcholine has been viewed as a mediator of learning and memory. Donepezil improves …

Protein phosphorylation, a key regulator of cellular processes, plays a central role in brain
function and is implicated in neurological disorders. Information on protein phosphorylation …

Technological advancements in next-generation DNA sequencing have enabled elucidation
of many genetic causes of neurodevelopmental disorders (NDDs) over the last two decades …

In the mammalian brain, NMDA receptors (NMDARs) activation triggers a calcium-
dependent signal transduction cascade resulting in postsynaptic remodeling and behavioral …