Novel purine derivatives as selective CDK2 inhibitors with potential anticancer activities: Design, synthesis and biological evaluation
Purine analogues were discovered to be inhibitors of CDK2, suggesting a potential
therapeutic scaffold. This paper addresses the design, synthesis, and anticancer evaluation …
therapeutic scaffold. This paper addresses the design, synthesis, and anticancer evaluation …
Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents
NM Panchani, HS Joshi - Russian Journal of Organic Chemistry, 2022 - Springer
Abstract A new series of 4-(1 H-imidazol-4-yl)-2-(substituted phenyl)-1, 4-dihydrobenzo [4, 5]
imidazo [1, 2-a] pyrimidines have been synthesized via a one-pot reaction using PEG-400 …
imidazo [1, 2-a] pyrimidines have been synthesized via a one-pot reaction using PEG-400 …
A Study on Leukemic and Non-small Cell Lung Cancer Efficacy of Novel Isoxazoles Synthesized by Microwave Irradiation
M Pandya, K Kapadiya - Letters in Drug Design & Discovery, 2021 - ingentaconnect.com
Background: The era of drug discovery suggested the designing of “hybrid drugs,” which
acquired recognition in the field of medicinal chemistry due to its influential role in …
acquired recognition in the field of medicinal chemistry due to its influential role in …
Carbamoyl 1, 4-Dihydropyridine Derivatives: Synthesis and Impressive Antidiabetic Activity
Dihydropyridine is known as one of the most important heterocyclic frameworks found in
numerous pharmaceuticals and drugs. A series of novel methyl 5-[(substituted phenyl) …
numerous pharmaceuticals and drugs. A series of novel methyl 5-[(substituted phenyl) …
Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold
KR Al-Jorani, AJK Atia, RI Al-Bayti - Russian Journal of Bioorganic …, 2021 - Springer
New hydrazinylidene derivatives were synthesized under appropriate conditions and in
excellent yields, by the reaction between a new [1, 3] thiazolo [3, 2-a] benzimidazol-2 (3H) …
excellent yields, by the reaction between a new [1, 3] thiazolo [3, 2-a] benzimidazol-2 (3H) …
Polar Solvent–Mediated Synthesis of Terminal Alkyne Derivatives of Thiazoles and Evaluation of Their Antidiabetic Activity
AJ Jivani, KM Kapadiya, RC Khunt - Russian Journal of Organic …, 2021 - Springer
Two new pharmacologically active series of N-alkyne-substituted indole–thiazoles and C-
alkyne-substituted benzylidene–thiazoles were synthesized by a two-step procedure …
alkyne-substituted benzylidene–thiazoles were synthesized by a two-step procedure …