The potential role of gut microbiota-derived metabolites as regulators of metabolic syndrome-associated mitochondrial and endolysosomal dysfunction in Alzheimer's …

YH Jung, CW Chae, HJ Han - Experimental & Molecular Medicine, 2024 - nature.com
Although the role of gut microbiota (GMB)-derived metabolites in mitochondrial and
endolysosomal dysfunction in Alzheimer's disease (AD) under metabolic syndrome remains …

Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms

Y Sun, A Mehmood, F Giampieri… - Critical reviews in food …, 2024 - Taylor & Francis
Diabetes is a metabolic disease due to impaired or defective insulin secretion and is
considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid …

[HTML][HTML] Hepatorenal protective efficacy of flavonoids from Ocimum basilicum extract in diabetic albino rats: A focus on hypoglycemic, antioxidant, anti-inflammatory …

MS Othman, AM Khaled, AH Al-Bagawi… - Biomedicine & …, 2021 - Elsevier
Plant derived phytochemical therapy is a bright candidate for treatment of diabetes and its
associated complications. Ocimum baslicum is used as an anti-diabetic traditional medicine …

GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats

A Hosseini Dastgerdi, M Sharifi, N Soltani - Scientific Reports, 2021 - nature.com
This study investigated the role of GABA in attenuating liver insulin resistance (IR) in type 2
diabetes parents and reducing its risk in their descendants' liver. Both sexes' rats were …

Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure

T Ku, J Hu, M Zhou, Y Xie, Y Liu, X Tan, L Guo… - Journal of …, 2024 - Elsevier
Tebuconazole exposure has been described as an increasing hazard to human health. An
increasing number of recent studies have shown a positive association between …

[HTML][HTML] Influences of cooking and storage on γ-aminobutyric acid (GABA) content and distribution in mung bean and its noodle products

Y Ma, A Wang, M Yang, S Wang, L Wang, S Zhou… - LWT, 2022 - Elsevier
The γ-aminobutyric acid (GABA) content and distribution of mung bean (MB), heat and
relative humidity treated MB (HRH-MB) under different cooking and storage conditions were …

The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide

MG Rad, M Sharifi, R Meamar, N Soltani - Nutrition & Diabetes, 2022 - nature.com
Background The present study investigated the effect of thiamine disulfide (TD) on the
pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic …

Hepatic global transcriptomic profiles of Holstein cows according to parity reveal age-related changes in early lactation

Z Cheng, C Ferris, MA Crowe, KL Ingvartsen… - International Journal of …, 2023 - mdpi.com
Cows can live for over 20 years, but their productive lifespan averages only around 3 years
after first calving. Liver dysfunction can reduce lifespan by increasing the risk of metabolic …

In Vivo and In Vitro Antidiabetic Efficacy of Aqueous and Methanolic Extracts of Orthosiphon Stamineus Benth

N Bassalat, S Kadan, S Melamed, T Yaron, Z Tietel… - Pharmaceutics, 2023 - mdpi.com
Orthosiphon stamineus is a popular folk herb used to treat diabetes and some other
disorders. Previous studies have shown that O. stamineus extracts were able to balance …

Intermittent Hypoxia Interferes with Autocrine Effects of GABA on Insulin Secretion in Postnatal Rodents—Implications for Pediatric Obstructive Sleep Apnea

EK Pae, MK Chung, RM Harper - Children, 2022 - mdpi.com
Gamma-amino butyric acid (GABA) is well known to help elevate pancreatic β cell vitality
and insulin levels in blood. GABA works via a coupling with GABA receptors; thus, the …