[HTML][HTML] Focus: Death: Organ dysfunction in sepsis: An ominous trajectory from infection to death

C Caraballo, F Jaimes - The Yale journal of biology and medicine, 2019 - ncbi.nlm.nih.gov
Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Acute kidney injury

C Ronco, R Bellomo, JA Kellum - The Lancet, 2019 - thelancet.com
Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine, decrease in
urine output, or both. AKI occurs in approximately 10–15% of patients admitted to hospital …

Extracellular DNA traps in inflammation, injury and healing

C Daniel, M Leppkes, LE Muñoz, G Schley… - Nature Reviews …, 2019 - nature.com
Following strong activation signals, several types of immune cells reportedly release
chromatin and granular proteins into the extracellular space, forming DNA traps. This …

[HTML][HTML] Role of perioperative hypotension in postoperative acute kidney injury: a narrative review

YR Lankadeva, CN May, R Bellomo… - British Journal of …, 2022 - Elsevier
Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Targeting oxidative stress in septic acute kidney injury: from theory to practice

CPC Ow, A Trask-Marino, AH Betrie, RG Evans… - Journal of Clinical …, 2021 - mdpi.com
Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

[HTML][HTML] Non-coding RNAs in kidney injury and repair

Z Liu, Y Wang, S Shu, J Cai… - American Journal of …, 2019 - journals.physiology.org
Acute kidney injury (AKI) is a major kidney disease featured by a rapid decline of renal
function. Pathologically, AKI is characterized by tubular epithelial cell injury and death …

Inhibition of the NADPH oxidase pathway reduces ferroptosis during septic renal injury in diabetic mice

W Yao, H Liao, M Pang, L Pan, Y Guan… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Obesity and type 2 diabetes mellitus (DM) contribute to a higher mortality rate
in patients with septic acute kidney injury (AKI) during sepsis. Reactive oxygen species …

The pathophysiology of sepsis-associated AKI

S Kuwabara, E Goggins, MD Okusa - Clinical Journal of the …, 2022 - journals.lww.com
Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …

Reversal of the pathophysiological responses to gram-negative sepsis by megadose vitamin C

YR Lankadeva, RM Peiris, N Okazaki… - Critical care …, 2021 - journals.lww.com
Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment
with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety …

[PDF][PDF] 肝素结合蛋白联合白介素-6 对持续性脓毒症急性肾损伤的预测价值

金仁华, 李静, 沈骁, 孙加奎, 穆心苇 - 临床急诊杂志, 2023 - lcjzen.whuhzzs.com
肝素结合蛋白联合白介素-6对持续性脓毒症急性肾损伤的预测价值 Page 1 2023年 临床急诊
杂志 24卷3期 JournalofClinicalEmergency(China) 引用本文:金仁华,李静,沈骁,等.肝素结合 …