Solid tumours are an enormous cancer burden and a major therapeutic challenge. The
cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for …

Tissues are three‐dimensional (3D) entities as is the tumor that arises within them. Though
disaggregated cancerous tissues have produced numerous cell lines for basic and applied …

Efficient delivery of therapeutics into tumor cells to increase the intracellular drug
concentration is a major challenge for cancer therapy due to drug resistance and inefficient …

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell
(CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct …

Tumor-initiating cells (T-ICs) are a subpopulation of chemoresistant tumor cells that have
been shown to cause tumor recurrence upon chemotherapy. Identification of T-ICs and their …

Cancers may arise from rare self-renewing tumor-initiating cells (T-IC). However, how T-IC
self renewal, multipotent differentiation, and tumorigenicity are maintained remains obscure …

Background The dismal survival of glioblastoma (GBM) patients urgently calls for the
development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive …

Transcriptome analysis has been a key area of biological inquiry for decades. Over the
years, research in the field has progressed from candidate gene-based detection of RNAs …

High-throughput genomic and proteomic technologies are widely used in cancer research to
build better predictive models of diagnosis, prognosis and therapy, to identify and …

Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer
associated with major morbidity and mortality. In this study, we determined that human …