Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

The treatment for metastatic castration-resistant prostate cancer patients remains a great
challenge in the clinic and continuously demands discoveries of new targets and therapies …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

The mammalian sirtuin family has attracted tremendous attention over the past few years as
stress adaptors and post-translational modifier. They have involved in diverse cellular …

Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-
dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian …

Exposure to ultraviolet (UV) radiation is associated with approximately 65% of melanoma
cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell carcinoma …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …