Schistosomes are parasitic worms that are a prime example of a complex multicellular
pathogen that flourishes in the human host despite the development of a pronounced …

Schistosomiasis is the second most important human parasitic disease in terms of
socioeconomic impact, causing great morbidity and mortality, predominantly across the …

Schistosomiasis japonica is a serious communicable disease and a major disease risk for
more than 30 million people living in the tropical and subtropical zones of China. Infection …

The occurrence of schistosomiasis within African infants and preschool children has been
much better documented in recent years, revealing an important burden of disease …

Background Schistosomiasis remains a global-health problem with over 90% of its burden
concentrated in Africa. Field studies reflect the complex ways in which socio-cultural and …

Schistosoma mansoni infection is highly endemic in parts of Uganda, and periportal fibrosis
is common in communities along the shore of Lake Albert. In this study, we have identified …

Hepatic periportal fibrosis, which affects 5–10% of subjects infected by Schistosoma
mansoni, is caused by the T cell-dependent granuloma that develop around schistosome …

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after
severe injury caused by autoimmune reactions, mechanical stress or infections. The …

Lethal disease due to hepatic periportal fibrosis occurs in 2%–10% of subjects infected by
Schistosoma mansoni in endemic regions such as Sudan. It is unknown why few infected …

Numerous investigations have revealed a bias toward males in the susceptibility to and
severity of a variety of infectious diseases, especially parasitic diseases. Although different …