Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

H Beraldo, D Gambino - Mini reviews in medicinal chemistry, 2004 - europepmc.org
The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …

Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides

S Liu - Advanced drug delivery reviews, 2008 - Elsevier
Receptor-based radiopharmaceuticals are of great current interest in molecular imaging and
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …

Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency

S Liu - Bioconjugate chemistry, 2009 - ACS Publications
Integrin αvβ3 plays a significant role in tumor angiogenesis and is a receptor for the
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …

Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

BM Paterson, PS Donnelly - Chemical Society Reviews, 2011 - pubs.rsc.org
The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM

F Dehdashti, MA Mintun, JS Lewis, J Bradley… - European journal of …, 2003 - Springer
Tumor hypoxia is recognized as an important determinant of response to therapy. In this
study we investigated the feasibility of clinical imaging with copper-60 diacetyl-bis (N 4 …

Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response—a preliminary report

F Dehdashti, PW Grigsby, MA Mintun, JS Lewis… - International Journal of …, 2003 - Elsevier
PURPOSE: Tumor hypoxia is associated with poor response to therapy. We have
investigated whether pretreatment tumor hypoxia assessed by positron emission …

A practical guide to the construction of radiometallated bioconjugates for positron emission tomography

BM Zeglis, JS Lewis - Dalton Transactions, 2011 - pubs.rsc.org
Positron emission tomography (PET) has become a vital imaging modality in the diagnosis
and treatment of disease, most notably cancer. A wide array of small molecule PET …

Unconventional nuclides for radiopharmaceuticals

JP Holland, MJ Williamson, JS Lewis - Molecular imaging, 2010 - journals.sagepub.com
Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy
of disease has been the driving force behind burgeoning research interests in the design of …