The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Biomembranes constitute a basis for all compartments of live cells, and therefore, the
monitoring of their lipid organization is essential for understanding cell status and activity …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

The rational design of drug delivery approaches leveraging supramolecular chemistry
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …