Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

The major histocompatibility complex (MHC) genomic region is composed of a group of
linked genes involved functionally with the adaptive and innate immune systems. The class I …

We have identified a novel family of human major histocompatibility complex (MHC) class I
genes. This MHC class I related gene family is defined by 10 members, among which 6 …

NKG2D, a prime activatory receptor on human NK, CD8+ αβ and γδ cells, has a variety of
ligands, which, despite sharing membership of the MHC class I structural club, display an …

Major histocompatibility complex (MHC) class I chain related (MIC) molecules show
homology with classical human leukocyte antigen (HLA) molecules, but they do not combine …

Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) in
Japan. We previously identified the association of SNP rs2596542 in the 5'flanking region of …

MICA is a stress-induced ligand of the NKG2D receptor that stimulates NK and T cell
responses and was identified as a key determinant of anti-tumor immunity. The MICA gene …

There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell
immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like …

We have been studying polymorphisms of HLA class I and II genes in East Asians including
Buryat in Siberia, Mongolian, Han Chinese, Man Chinese, Korean Chinese, South Korean …

The MICA gene has a high degree of polymorphism. Allelic variation of MICA may influence
binding of these ligands to the NK cell receptor NKG2D and may affect organ transplantation …