Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Abstract Hypothalamic-pituitary-adrenal (HPA) axis function may change over the course of
aging, and altered diurnal or stress-induced secretion of the hormone cortisol could …

In a world with an ageing population, dementia has become an urgent threat to global health
and wellbeing. Psychosocial and lifestyle factors, such as higher socioeconomic positions …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

A lifecourse perspective is key for understanding and interpreting racial and ethnic patterns
in neuropsychological test performance. In this article, we discuss contextual factors that …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

The physiological consequences of acute and chronic stress on a range of organ systems
have been well documented after the pioneering work of Hans Selye more than 70 years …

Background Despite evidence that psychological stress is an important risk factor for age-
related cognitive loss, little research has directly evaluated psychological and physiological …

Background We systematically reviewed and meta-analyzed the association of late-life
depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of …

Stress exerts complex effects on the brain and periphery, dependent on the temporal profile
and intensity of the stressor. The consequences of a stressful event can also be determined …