CK2 (formerly termed “casein kinase 2”) is a ubiquitous, highly pleiotropic and constitutively
active Ser/Thr protein kinase whose implication in neoplasia, cell survival, and virus …

Protein kinase CK2 is a pleiotropic, ubiquitous and constitutively active protein kinase that
can use both ATP and GTP as phosphoryl donors with specificity for serine/threonine …

Many replication events are involved in the influenza A virus life cycle, and they are
accomplished by different virus proteins with specific functions. However, because the size …

The outbreaks of avian influenza A virus in poultry and humans over the last decade posed
a pandemic threat to human. Here, we discuss the basic classification and the structure of …

The influenza A virus RNA-dependent RNA polymerase consists of three subunits—PB1,
PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the …

The RNA-dependent RNA polymerase of influenza virus is a heterotrimer formed by the
PB1, PB2, and PA subunits. Although PA is known to be required for polymerase activity, its …

Protein phosphorylation is a common post-translational modification in eukaryotic cells and
has a wide range of functional effects. Here, we used mass spectrometry to search for …

Avian influenza viruses have adapted to human hosts, causing pandemics in humans. The
key host-specific amino acid mutations required for an avian influenza virus to function in …

The phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway has attracted much recent
interest due to its central role in modulating diverse downstream signalling pathways …

Influenza virus ribonucleoproteins (RNPs) were reconstituted in vivo from cloned cDNAs
expressing the three polymerase subunits, the nucleoprotein (NP), and short template …