Biotransformation is a process by which organic compounds are transformed from one form
to another, aided by organisms such as bacteria, fungi and enzymes. Biotransformations are …

Screening for novel producer strains and enhanced therapeutic production at reduced cost
has been the focus of most of the biopharmaceutical industries. The obligation to carry out …

Discovering a new drug is a complex but sequential process from discovery to preclinical
development, followed with clinical drug development. It has been estimated that∼ 87% of …

The sulfonylurea urea drug glyburide (glibenclamide) is widely used for the treatment of
diabetes milletus and gestational diabetes. In previous studies monohydroxylated …

Intensive Biotransformation studies on Gefitinib could play a significant role in designing and
synthesizing new drugs around the core structure of Gefitinib. These studies may be useful …

Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its
metabolites. Drug metabolism studies are based on the characterization of the structure of …

Studies were conducted on the Metabolism of sulfonylurea drug glyburide (5-chloro-N-(4-[N-
(cyclohexylcarbamoyl) sulfamoyl] phenethyl)-2-methoxybenzamide) in human, mouse, rat …

In vitro Biotransformation studies play a crucial role in drug discovery program that
determine the fate of the new chemical entities (NCE's). Enzyme rich matrices such as …

Mass spectrometry has made tremendous advancement during the last decade. This
progress has led to the advent of entirely new instruments/technologies and has …

Human health is always promoted by vitamins and minerals derived from vegetables and
fruits. However, increased usage of pesticides for high yield poses a significant threat to …