Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation
YC Boo - Antioxidants, 2021 - mdpi.com
Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which
leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and …
leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and …
The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases
CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
JD Zeidler, KA Hogan, G Agorrody… - … of Physiology-Cell …, 2022 - journals.physiology.org
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
Targeting two-pore channels: current progress and future challenges
Two-pore channels (TPCs) are cation-permeable channels located on endolysosomal
membranes and important mediators of intracellular Ca 2+ signalling. TPCs are involved in …
membranes and important mediators of intracellular Ca 2+ signalling. TPCs are involved in …
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells
ABSTRACT CD38 is a cell surface receptor capable of generating calcium-mobilizing
second messengers. It has been implicated in host defense and cancer biology, but …
second messengers. It has been implicated in host defense and cancer biology, but …
CD38 promotes angiotensin II‐induced cardiac hypertrophy
XH Guan, X Hong, N Zhao, XH Liu… - Journal of cellular …, 2017 - Wiley Online Library
Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and
regulated by various signalling pathways. Recently, we observed that mouse embryonic …
regulated by various signalling pathways. Recently, we observed that mouse embryonic …
[HTML][HTML] Two-pore channels and disease
S Patel, BS Kilpatrick - Biochimica Et Biophysica Acta (BBA)-Molecular Cell …, 2018 - Elsevier
Two-pore channels (TPCs) are Ca 2+-permeable endo-lysosomal ion channels subject to
multi-modal regulation. They mediate their physiological effects through releasing Ca 2+ …
multi-modal regulation. They mediate their physiological effects through releasing Ca 2+ …
Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases
J Feng, MK Armillei, AS Yu, BT Liang… - Journal of …, 2019 - mdpi.com
Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac
fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including …
fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including …
Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced …
CD38 enzymatic activity regulates NAD+ and cADPR levels in mammalian tissues, and
therefore has a prominent role in cellular metabolism and calcium homeostasis …
therefore has a prominent role in cellular metabolism and calcium homeostasis …
The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research
M Kitada, S Araki, D Koya - Cells, 2023 - mdpi.com
Aging is a major risk factor for the leading causes of mortality, and the incidence of age-
related diseases including cardiovascular disease, kidney disease and metabolic disease …
related diseases including cardiovascular disease, kidney disease and metabolic disease …