Key advances in vaccine development for tuberculosis—Success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …
The role of engineered materials in mucosal vaccination strategies
Mucosal pathogens, as exemplified by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), human immunodeficiency virus (HIV) and Mycobacterium tuberculosis, lead …
(SARS-CoV-2), human immunodeficiency virus (HIV) and Mycobacterium tuberculosis, lead …
Advances in protein subunit vaccines against tuberculosis
Y Zhang, J Xu, Z Hu, X Fan - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium
tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any …
tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any …
[HTML][HTML] T cell control of SARS-CoV-2: When, which, and where?
MO Diniz, MK Maini, L Swadling - Seminars in Immunology, 2023 - Elsevier
Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated
activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells …
activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells …
A multistage Sendai virus vaccine incorporating latency-associated antigens induces protection against acute and latent tuberculosis
Z Hu, J Xia, J Wu, H Zhao, P Ji, L Gu, W Gu… - Emerging Microbes & …, 2024 - Taylor & Francis
One-quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb).
After initial exposure, more immune-competent persons develop asymptomatic latent …
After initial exposure, more immune-competent persons develop asymptomatic latent …
Vaccine Strategies to Elicit Mucosal Immunity
Y Song, F Mehl, SL Zeichner - Vaccines, 2024 - mdpi.com
Vaccines are essential tools to prevent infection and control transmission of infectious
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …
[HTML][HTML] Inhaled aerosol viral-vectored vaccines against tuberculosis
E Stylianou, I Satti - Current Opinion in Virology, 2024 - Elsevier
Bacille Calmette-Guérin (BCG) remains the sole licensed vaccine against tuberculosis (TB),
despite its variable efficacy in protecting against pulmonary TB. The development of effective …
despite its variable efficacy in protecting against pulmonary TB. The development of effective …
Immunogenicity and protective efficacy of RipA, a peptidoglycan hydrolase, against Mycobacterium tuberculosis Beijing outbreak strains
KW Kwon, HG Choi, HH Choi, E Choi, H Kim, HJ Kim… - Vaccine, 2024 - Elsevier
Given that individuals with latent tuberculosis (TB) infection represent the major reservoir of
TB infection, latency-associated antigens may be promising options for development of …
TB infection, latency-associated antigens may be promising options for development of …
[HTML][HTML] Humanized Mouse Models of Bacterial Infections
K McDonald, A Rodriguez, G Muthukrishnan - Antibiotics, 2024 - mdpi.com
Bacterial infections continue to represent a significant healthcare burden worldwide, causing
considerable mortality and morbidity every year. The emergence of multidrug-resistant …
considerable mortality and morbidity every year. The emergence of multidrug-resistant …
Immunopathology of Pulmonary Mycobacterium tuberculosis Infection in a Humanized Mouse Model
Despite the availability of antibiotic therapy, tuberculosis (TB) is prevailing as a leading killer
among human infectious diseases, which highlights the need for better intervention …
among human infectious diseases, which highlights the need for better intervention …