Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-
inflammatory cytokines and neuroinflammation are important not only in inflammatory …

The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …

Gut-brain axis is a dynamic, complex, and bidirectional communication network between the
gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …

Alterations in cortical thickness have been identified in major depressive disorder (MDD),
but findings have been variable and inconsistent. To date, no reliable tools have been …

Despite that burnout presents a serious burden for modern society, there are no diagnostic
criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …

Structural hippocampal abnormalities are common in many neurological and psychiatric
disorders, and variation in hippocampal measures is related to cognitive performance and …

HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …