Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

New insight into circRNAs: characterization, strategies, and biomedical applications

XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …

Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …

Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarks

L Meng, H Wu, J Wu, P Ding, J He, M Sang… - Cell Death & Disease, 2024 - nature.com
Current treatment strategies for cancer, especially advanced cancer, are limited and
unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades …

A circular RNA-gawky-chromatin regulatory axis modulates stress-induced transcription

R Su, M Zhou, J Lin, G Shan… - Nucleic Acids Research, 2024 - academic.oup.com
In response to heavy metal stress, the RNA-binding protein (RBP) gawky translocates into
the nucleus and acts as a chromatin-interacting factor to activate the transcription of many …

A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate …

R Wang, J Zhong, X Pan, Z Su, Y Xu, M Zhang… - Journal of Translational …, 2023 - Springer
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway
that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB …

circRNA: a promising all-around star in the future

H Li - Epigenomics, 2023 - Taylor & Francis
circRNA is a type of RNA molecule with a circular structure. From initially thinking it was
useless to now discovering that it has important and complex functions, the importance of …

Evolutionary conserved circular MEF2A RNAs regulate myogenic differentiation and skeletal muscle development

X Shen, X Zhao, H He, J Zhao, Y Wei, Y Chen… - PLoS …, 2023 - journals.plos.org
Circular RNAs (circRNAs) have been recognized as critical regulators of skeletal muscle
development. Myocyte enhancer factor 2A (MEF2A) is an evolutionarily conserved …

CircR-looping the leukemic translocations: The cause of MLL translocations explained

M Chen - Molecular Cell, 2023 - cell.com
Conn et al. 1 identify circular RNAs (circRNAs) derived from mixed lineage leukemia (MLL)
breakpoint cluster regions, demonstrating a causal role of circRNAs in MLL translocations …

Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function

SM Cao, H Wu, GH Yuan, YH Pan, J Zhang, YX Liu… - Molecular Cell, 2024 - cell.com
Circular RNAs (circRNAs) are upregulated during neurogenesis. Where and how circRNAs
are localized and what roles they play during this process have remained elusive …