Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …

COVID‐19 is characterized by dysregulated immune responses, metabolic dysfunction and
adverse effects on the function of multiple organs. To understand host responses to COVID …

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …

Heterozygous signal transducer and activator of transcription 1 (STAT1) gain-of-function
(GOF) mutations promote a clinical syndrome of immune dysregulation characterized by …

Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …

The genus Ebolavirus from the family Filoviridae is composed of five species including
Sudan ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus, Taï Forest ebolavirus, and …

Abstract Background In 2014, Western Africa experienced an unanticipated explosion of
Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely …