The 2022 report on the human proteome from the HUPO human proteome project
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections
Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …
of viral spread. However, it remains unclear how cells in close or distant proximity to an …
Hepatitis C virus alters the morphology and function of peroxisomes
E Martin de Fourchambault, N Callens… - Frontiers in …, 2023 - frontiersin.org
Despite the introduction of effective treatments for hepatitis C in clinics, issues remain
regarding the liver disease induced by chronic hepatitis C virus (HCV) infection. HCV is …
regarding the liver disease induced by chronic hepatitis C virus (HCV) infection. HCV is …
DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
JL Justice, TJ Reed, B Phelan, TM Greco, JE Hutton… - Cell Systems, 2024 - cell.com
The DNA-dependent protein kinase, DNA-PK, is an essential regulator of DNA damage
repair. DNA-PK-driven phosphorylation events and the activated DNA damage response …
repair. DNA-PK-driven phosphorylation events and the activated DNA damage response …
Infection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics
WA Hofstadter, KC Cook, E Tsopurashvili… - Nature …, 2024 - nature.com
The dynamic regulation of mitochondria shape via fission and fusion is critical for cellular
responses to stimuli. In homeostatic cells, two modes of mitochondrial fission, midzone and …
responses to stimuli. In homeostatic cells, two modes of mitochondrial fission, midzone and …
Super-resolution microscopy to study interorganelle contact sites
JA Nieto-Garai, J Olazar-Intxausti, I Anso… - International Journal of …, 2022 - mdpi.com
Interorganelle membrane contact sites (MCS) are areas of close vicinity between the
membranes of two organelles that are maintained by protein tethers. Recently, a significant …
membranes of two organelles that are maintained by protein tethers. Recently, a significant …
Viral regulation of organelle membrane contact sites
WA Hofstadter, E Tsopurashvili, IM Cristea - PLoS biology, 2024 - journals.plos.org
At the core of organelle functions lies their ability and need to form dynamic organelle–
organelle networks that drive intracellular communication and coordination of cellular …
organelle networks that drive intracellular communication and coordination of cellular …
Metal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling
Q Jiang, H Wang, Z Qiao, Y Hou, Z Sui, B Zhao… - Chemical …, 2023 - pubs.rsc.org
Systematically dissecting the highly dynamic and tightly communicating membrane
proteome of living cells is essential for the system-level understanding of fundamental …
proteome of living cells is essential for the system-level understanding of fundamental …
A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets
Effective intracellular communication between cellular organelles occurs at dedicated
membrane contact sites (MCSs). Tether proteins are responsible for the establishment of …
membrane contact sites (MCSs). Tether proteins are responsible for the establishment of …