For the successful X-ray structure determination of macromolecules, it is first necessary to
identify, usually by matrix screening, conditions that yield some sort of crystals. Initial crystals …

Numerous reports have been published in the literature which describe the crystallization of
macromolecules by a variety of crystallization methods, including the vapour-diffusion and …

X-ray crystallography is an established method for studying the structure of proteins and
other macromolecules. As the importance of proteins grows, researchers in many fields have …

Protein crystals have many important applications in many fields, including pharmaceutics.
Being more stable than other formulations, and having a high degree of purity and …

The process of protein crystallization often takes place too rapidly, thus producing showers
of crystals instead of large single crystals. A novel technique for improving protein-crystal …

Very high quality crystals of tetragonal hen egg-white lysozyme were grown in the Advanced
Protein Crystallization Facility (APCF) on board the Space Shuttle using a modified free …

Abstract B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated
apoptosis. We have investigated the structure and function of the least characterized Bcl-2 …

Macromolecular X-ray crystallography underpins the vigorous field of structural molecular
biology having yielded many protein, nucleic acid and virus structures in fine detail. The …

The occurrence of convective flows during crystal growth is believed to adversely affect
crystal quality. Space-based crystal growth is therefore actively pursued, particularly for …

The physicochemical aspects of protein crystallization in reduced-gravity environments (µg)
have been investigated with the Advanced Protein Crystallization Facility during six space …