Virulence factors of the Mycobacterium tuberculosis complex

MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion

JA Hyde - Frontiers in immunology, 2017 - frontiersin.org
Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage,
inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic …

HtrA protease family as therapeutic targets

J Skorko-Glonek, D Zurawa-Janicka… - Current …, 2013 - ingentaconnect.com
The HtrA proteases degrade damaged proteins and thus control the quality of proteins and
protect cells against the consequences of various stresses; they also recognize specific …

Engineering of serine protease for improved thermostability and catalytic activity using rational design

NM Ashraf, A Krishnagopal, A Hussain… - International journal of …, 2019 - Elsevier
The study involves the isolation and characterization of a serine peptidase, named SP, from
Pseudomonas aeruginosa. In addition to basic characterization, the protein was engineered …

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

G Hansen, R Hilgenfeld - Cellular and Molecular Life Sciences, 2013 - Springer
Protein quality control is vital for all living cells and sophisticated molecular mechanisms
have evolved to prevent the excessive accumulation of unfolded proteins. High-temperature …

Tea polyphenol liposomes overcome gastric mucus to treat helicobacter pylori infection and enhance the intestinal microenvironment

G Deng, Y Wu, Z Song, S Li, M Du, J Deng… - … Applied Materials & …, 2022 - ACS Publications
Infection with Helicobacter pylori (Hp) is one of the leading causes of stomach cancer. The
ability to treat Hp infection is hampered by a lack of stomach gastric acid environment. This …

Structural insights into the activation mechanisms of human HtrA serine proteases

D Zurawa-Janicka, T Wenta, M Jarzab… - Archives of biochemistry …, 2017 - Elsevier
Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine
proteases and function as important modulators of many physiological processes, including …

Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease

I Di Donato, S Bianchi, GN Gallus… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims Cerebral small vessel disease (SVD) is the leading cause of vascular dementia.
Although the most of cases are sporadic, familial monogenic causes have been identified in …

Processing of D1 protein: a mysterious process carried out in thylakoid lumen

N Inagaki - International Journal of Molecular Sciences, 2022 - mdpi.com
In oxygenic photosynthetic organisms, D1 protein, a core subunit of photosystem II (PSII),
displays a rapid turnover in the light, in which D1 proteins are distinctively damaged and …

Function of serine protease HtrA in the lifecycle of the foodborne pathogen Campylobacter jejuni

M Boehm, D Simson, U Escher, AM Schmidt… - European Journal of …, 2018 - akjournals.com
Campylobacter jejuni is a major food-borne zoonotic pathogen, responsible for a large
proportion of bacterial gastroenteritis cases, as well as Guillian-Barré and Miller-Fisher …