New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Macrocyclization and backbone modification in RiPP biosynthesis
H Lee, WA Van Der Donk - Annual review of biochemistry, 2022 - annualreviews.org
The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …
Bioinformatic atlas of radical SAM enzyme-modified RiPP natural products reveals an isoleucine–tryptophan crosslink
KA Clark, MR Seyedsayamdost - Journal of the American …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …
family of natural products with diverse activities and structures. RiPP classes are defined by …
Radical SAM-dependent ether crosslink in daropeptide biosynthesis
Darobactin is a ribosomally synthesized and post-translationally modified peptide (RiPP),
which possesses potent activity against various Gram-negative bacteria. Darobactin features …
which possesses potent activity against various Gram-negative bacteria. Darobactin features …
The hidden enzymology of bacterial natural product biosynthesis
TA Scott, J Piel - Nature Reviews Chemistry, 2019 - nature.com
Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …
them with a remarkable range of biological activities that are of significant value to modern …
Discovery and biosynthesis of streptosactin, a sactipeptide with an alternative topology encoded by commensal bacteria in the human microbiome
LB Bushin, BC Covington, BE Rued… - Journal of the …, 2020 - ACS Publications
Mammalian microbiomes encode thousands of biosynthetic gene clusters (BGCs) and
represent a new frontier in natural product research. We recently found an abundance of …
represent a new frontier in natural product research. We recently found an abundance of …
Bacterial cyclophane-containing RiPPs from radical SAM enzymes
CS Phan, BI Morinaka - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2016 to 2023 Ribosomally synthesized and posttranslationally modified peptides
(RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural …
(RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural …
Charting an unexplored streptococcal biosynthetic landscape reveals a unique peptide cyclization motif
Peptide natural products are often used as signals or antibiotics and contain unusual
structural modifications, thus providing opportunities for expanding our understanding of …
structural modifications, thus providing opportunities for expanding our understanding of …
Trapping a cross-linked lysine–tryptophan radical in the catalytic cycle of the radical SAM enzyme SuiB
The radical S-adenosylmethionine (rSAM) enzyme SuiB catalyzes the formation of an
unusual carbon–carbon bond between the sidechains of lysine (Lys) and tryptophan (Trp) in …
unusual carbon–carbon bond between the sidechains of lysine (Lys) and tryptophan (Trp) in …
Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an
ascendant class of natural products with diverse structures and functions. Recently, we …
ascendant class of natural products with diverse structures and functions. Recently, we …