Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9
(Cas9) is a precise genome manipulating technology that can be programmed to induce …

RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Timely and faithful duplication of the entire genome depends on completion of replication.
Replication forks frequently encounter obstacles that may cause genotoxic fork stalling …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope.
Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to …

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …