Gradient scaffolds for osteochondral tissue engineering and regeneration

B Zhang, J Huang, RJ Narayan - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
The tissue engineering approach for repairing osteochondral (OC) defects involves the
fabrication of a biological tissue scaffold that mimics the physiological properties of natural …

Three-dimensional printing of multilayered tissue engineering scaffolds

SM Bittner, JL Guo, A Melchiorri, AG Mikos - Materials today, 2018 - Elsevier
The field of tissue engineering has produced new therapies for the repair of damaged
tissues and organs, utilizing biomimetic scaffolds that mirror the mechanical and biological …

Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits

Y Du, H Liu, Q Yang, S Wang, J Wang, J Ma, I Noh… - Biomaterials, 2017 - Elsevier
Osteochondral defects cannot be adequately self-repaired due to the presence of the
sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the …

3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction

L Chen, C Deng, J Li, Q Yao, J Chang, L Wang, C Wu - Biomaterials, 2019 - Elsevier
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by
degenerative diseases. The simultaneous regeneration of both cartilage and subchondral …

Mathematically defined tissue engineering scaffold architectures prepared by stereolithography

FPW Melchels, K Bertoldi, R Gabbrielli, AH Velders… - Biomaterials, 2010 - Elsevier
The technologies employed for the preparation of conventional tissue engineering scaffolds
restrict the materials choice and the extent to which the architecture can be designed. Here …

Electrospun polycaprolactone 3D nanofibrous scaffold with interconnected and hierarchically structured pores for bone tissue engineering

T Xu, JM Miszuk, Y Zhao, H Sun… - Advanced healthcare …, 2015 - Wiley Online Library
For the first time, electrospun polycaprolactone (PCL) 3D nanofibrous scaffold has been
developed by an innovative and convenient approach (ie, thermally induced nanofiber self …

Ceramics for medical applications: A picture for the next 20 years

J Chevalier, L Gremillard - Journal of the European Ceramic Society, 2009 - Elsevier
High-tech ceramics have always been associated to medical devices: they are used today
as femoral heads and acetabular cups for total hip replacement, dental implants and …

Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds

NE Fedorovich, W Schuurman… - … Engineering Part C …, 2012 - liebertpub.com
Osteochondral defects are prone to induce osteoarthritic degenerative changes. Many tissue-
engineering approaches that aim to generate osteochondral implants suffer from poor tissue …

3D bioprinting of hydrogel constructs with cell and material gradients for the regeneration of full-thickness chondral defect using a microfluidic printing head

J Idaszek, M Costantini, TA Karlsen, J Jaroszewicz… - …, 2019 - iopscience.iop.org
Osteochondral (OC) tissue is a biphasic material comprised of articular cartilage integrated
atop subchondral bone. Damage to this tissue is highly problematic, owing to its intrinsic …

Definition and classification of early osteoarthritis of the knee

FP Luyten, M Denti, G Filardo, E Kon… - Knee Surgery, Sports …, 2012 - Springer
With the emerging interest in regenerative medicine and tissue engineering, new treatment
modalities being developed for joint disorders including joint surface lesions and articular …