Macrophages and foam cells: Brief overview of their role, linkage, and targeting potential in atherosclerosis

AV Poznyak, NG Nikiforov, AV Starodubova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is still one of the main causes of death around the globe. This condition
leads to various life-threatening cardiovascular complications. However, no effective …

Effects of Lipoic Acid on Ischemia‐Reperfusion Injury

Y Ding, Y Zhang, W Zhang, J Shang… - … medicine and cellular …, 2021 - Wiley Online Library
Ischemia‐reperfusion (I/R) injury often occurred in some pathologies and surgeries. I/R
injury not only harmed to physiological functions of corresponding organ and tissue but also …

Icariin, an up-and-coming bioactive compound against neurological diseases: network pharmacology-based study and literature review

S Wang, J Ma, Y Zeng, G Zhou, Y Wang… - Drug design …, 2021 - Taylor & Francis
Icariin is a biologically active substance in Epimedii herba that is used for the treatment of
neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of …

Advances in the study of S100A9 in cardiovascular diseases

F Chen, Z He, C Wang, J Si, Z Chen, Y Guo - Cell Proliferation, 2024 - Wiley Online Library
Cardiovascular disease (CVD) is a group of diseases that primarily affect the heart or blood
vessels, with high disability and mortality rates, posing a serious threat to human health. The …

[HTML][HTML] Pre-operative neutrophil to lymphocyte ratio is associated with 30 day death or amputation after revascularisation for acute limb ischaemia

NH Coelho, A Coelho, R Augusto, C Semiao… - European Journal of …, 2021 - Elsevier
Objective Inflammation is an early feature of acute limb ischaemia (ALI), hence the potential
prognostic significance of inflammatory biomarkers. This study aimed to assess the value of …

Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway

J Liu, P Qiu, J Qin, X Wu, X Wang, X Yang, B Li… - Stem Cells, 2020 - academic.oup.com
Adipose-derived mesenchymal stem cells (ASCs) are multipotent stromal cells that possess
considerable therapeutic potential for tissue remodeling. However, their protective …

Notoginsenoside R1 activates the Ang2/Tie2 pathway to promote angiogenesis

J Zhong, W Lu, J Zhang, M Huang, W Lyu, G Ye… - Phytomedicine, 2020 - Elsevier
Background Therapeutic angiogenesis is a novel strategy for the treatment of ischemic
diseases that involves promotion of angiogenesis in ischemic tissues via the use of …

Tourniquet‐induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice

B Packialakshmi, IJ Stewart, DM Burmeister… - Physiological …, 2022 - Wiley Online Library
The mechanisms by which lower limb ischemia/reperfusion induces acute kidney injury
(AKI) remain largely uncharacterized. We hypothesized that tourniquet‐induced lower limb …

Current progress in messenger RNA-based gene therapy

S Lei, X Zhang, J Li, Y Gao, J Wu… - Journal of Biomedical …, 2020 - ingentaconnect.com
Based on its rapid expression, simple sequence composition, low immunogenicity, and
flexible modification possibilities, in vitro synthesized mRNA has demonstrated strong …

Stem cell therapy in limb ischemia: state-of-art, perspective, and possible impacts of endometrial-derived stem cells

S Khodayari, H Khodayari… - Frontiers in Cell and …, 2022 - frontiersin.org
As an evidence-based performance, the rising incidence of various ischemic disorders has
been observed across many nations. As a result, there is a growing need for the …