Research Progress on the Structure and Function of G3BP

W Kang, Y Wang, W Yang, J Zhang, H Zheng… - Frontiers in …, 2021 - frontiersin.org
Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …

CDK9: A key player in cancer and other diseases

LC Franco, F Morales, S Boffo… - Journal of Cellular …, 2018 - Wiley Online Library
Abstract Cyclin‐Dependent Kinase 9 (CDK9) is part of a functional diverse group of
enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin …

MicroRNA as a therapeutic target in cardiac remodeling

C Chen, M Ponnusamy, C Liu, J Gao… - BioMed research …, 2017 - Wiley Online Library
MicroRNAs (miRNAs) are small RNA molecules that contain 18–25 nucleotides. The
alterations in their expression level play crucial role in the development of many disorders …

[HTML][HTML] The role of microRNAs in heart failure

H Wang, J Cai - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
MicroRNAs are small non-coding RNA molecules that regulate gene expression by
inhibiting mRNA translation and/or inducing mRNA degradation. In the past decade, many in …

[HTML][HTML] Rasputin a decade on and more promiscuous than ever? A review of G3BPs

U Alam, D Kennedy - Biochimica Et Biophysica Acta (BBA)-Molecular Cell …, 2019 - Elsevier
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BPs, also known as
Rasputin) are a family of RNA binding proteins that regulate gene expression in response to …

The roles of G3BP1 in human diseases

Y Ge, J Jin, J Li, M Ye, X Jin - Gene, 2022 - Elsevier
Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional binding
protein involved in a variety of biological functions, including cell proliferation, metastasis …

Regulating microRNA expression: at the heart of diabetes mellitus and the mitochondrion

QA Hathaway, MV Pinti, AJ Durr… - American Journal …, 2018 - journals.physiology.org
Type 2 diabetes mellitus is a major risk factor for cardiovascular disease and mortality.
Uncontrolled type 2 diabetes mellitus results in a systemic milieu of increased circulating …

Heart failure: Pilot transcriptomic analysis of cardiac tissue by RNA-sequencing

C Schiano, V Costa, M Aprile, V Grimaldi… - Cardiology …, 2017 - journals.viamedica.pl
Background: Despite left ventricular (LV) dysfunction contributing to mortality in chronic heart
failure (HF), the molecular mechanisms of LV failure continues to remain poorly understood …

Expression profile of microRNAs in hypertrophic cardiomyopathy and effects of microRNA-20 in inducing cardiomyocyte hypertrophy through regulating gene MFN2

D Sun, C Li, J Liu, Z Wang, Y Liu, C Luo… - DNA and cell …, 2019 - liebertpub.com
Myocardial hypertrophy is an important cause of heart failure and sudden death. Studies
have shown that Mitofusin-2 (MFN2) is downregulated in myocardial hypertrophy, but the …

G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway

H Hong, J Lu, X Fang, Y Zhang, Y Cai, J Yuan… - Acta Pharmacologica …, 2018 - nature.com
The RasGAP SH3 domain-binding proteins (G3BPs) are a family of RNA-binding proteins
that can co-ordinate signal transduction and post-transcriptional gene regulation. G3BPs …