Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease
from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein …

In hypertrophic hearts, autophagic flux insufficiency is recognized as a key pathology
leading to maladaptive cardiac remodeling and heart failure. This study aimed to illuminate …

Pancreatic β cell dysfunction and reduction due to glucose toxicity play a crucial role in the
development of type 2 diabetes mellitus (T2DM). Irisin, a novel exercise-induced myokine …

A comprehensive understanding of endothelial cell lineage specification will advance
cardiovascular regenerative medicine. Recent studies found that unique epigenetic …

Background Exercise is a major nonpharmacological treatment for hypertension, but its
underlying mechanisms are still not completely elucidated. Irisin, a polypeptide containing …

This review is focused on the mechanisms that regulate health, disease and aging redox
status, the signal pathways that counteract oxidative and reductive stress, the role of food …

The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular
diseases owing to fat mass excess has been described. In recent years, muscle …

Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …