Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …

There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-
like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer …

The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive …

CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

As a substantial part of the brain tumor microenvironment (TME), glioma-associated
microglia/macrophages (GAMs) have an emerging role in tumor progression and in …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Glioblastomas (glioblastoma multiforme, GBM) are one of the most recalcitrant brain tumors
because of their aggressive invasive growth and resistance to therapy. They are highly …

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …