Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
[HTML][HTML] Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms
Y Chen, X Shao, X Zhao, Y Ji, X Liu, P Li… - Biomedicine & …, 2021 - Elsevier
The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression
J Zhang, X Fan, Y Zhou, L Chen, H Rao - Journal of Experimental & …, 2022 - Springer
Background Downregulation of epithelial markers and upregulation of mesenchymal
markers are the characteristics of the epithelial to mesenchymal transition (EMT) program …
markers are the characteristics of the epithelial to mesenchymal transition (EMT) program …
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Abstract Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …
PRMT5: a putative oncogene and therapeutic target in prostate cancer
E Beketova, JL Owens, AM Asberry, CD Hu - Cancer gene therapy, 2022 - nature.com
Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …
Preventing neurodegeneration by controlling oxidative stress: the role of OXR1
MR Volkert, DJ Crowley - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal
damage resulting from ischemia are among the notable neurodegenerative diseases in …
damage resulting from ischemia are among the notable neurodegenerative diseases in …
[HTML][HTML] N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
A Quiles-Jiménez, I Gregersen, MML de Sousa… - Biochemical and …, 2020 - Elsevier
Background More than 170 post-transcriptional RNA modifications regulate the localization,
processing and function of cellular RNAs, and aberrant RNA modifications have been linked …
processing and function of cellular RNAs, and aberrant RNA modifications have been linked …
Histone methylation related therapeutic challenge in cardiovascular diseases
Y Yang, Y Luan, RX Yuan, Y Luan - Frontiers in Cardiovascular …, 2021 - frontiersin.org
The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced
countries accompanied by the high prevalence of risk factors. In terms of pathogenesis, the …
countries accompanied by the high prevalence of risk factors. In terms of pathogenesis, the …
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour
E Castroflorio, J Den Hoed, D Svistunova… - Cellular and Molecular …, 2021 - Springer
Abstract Members of the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc)
protein family are associated with multiple neurodevelopmental disorders, although their …
protein family are associated with multiple neurodevelopmental disorders, although their …
H2O2 induces major phosphorylation changes in critical regulators of signal transduction, gene expression, metabolism and developmental networks in Aspergillus …
U Carrasco-Navarro, J Aguirre - Journal of Fungi, 2021 - mdpi.com
Reactive oxygen species (ROS) regulate several aspects of cell physiology in filamentous
fungi including the antioxidant response and development. However, little is known about …
fungi including the antioxidant response and development. However, little is known about …