Biomaterials have had an increasingly important role in recent decades, in biomedical
device design and the development of tissue engineering solutions for cell delivery, drug …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Current intra-articular drug delivery methods do not guarantee sufficient drug penetration
into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit …

Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell
differentiation in the host immune response; however, the uncontrollable stimulation of NF …

Osteoclasts are highly specialized cells of haematopoietic lineage that are uniquely
responsible for bone resorption. In the past, osteoclasts were isolated as mature cells from …

The class of small leucine-rich proteoglycans (SLRPs) is a family of homologous
proteoglycans harboring relatively small (36–42 kDa) protein cores compared with the larger …

Patients affected by Duchenne muscular dystrophy (DMD) and dystrophic MDX mice were
investigated in this study for their bone phenotype and systemic regulators of bone turnover …

Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

Mechanical loading represents a crucial factor in the regulation of skeletal homeostasis. Its
reduction causes loss of bone mass, eventually leading to osteoporosis. In a previous global …

Bone and cartilage are connective tissues with distinct organic matrix (collagen and non‐
collagenous proteins) composition facilitating their biological function. Proteoglycans (PGs) …