SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

A Idris, A Davis, A Supramaniam, D Acharya, G Kelly… - Molecular Therapy, 2021 - cell.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there …

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

AA Amarilla, JDJ Sng, R Parry, JM Deerain… - Nature …, 2021 - nature.com
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …

Quantification methods for viruses and virus-like particles applied in biopharmaceutical production processes

K Lothert, F Eilts, MW Wolff - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Effective cell-based production processes of virus particles are the foundation
for the global availability of classical vaccines, gene therapeutic vectors, and viral oncolytic …

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

CLD McMillan, JJY Choo, A Idris, A Supramaniam… - Science …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
160 million people and resulted in more than 3.3 million deaths, and despite the availability …

[HTML][HTML] No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing

N Smits, J Rasmussen, GO Bodea, AA Amarilla… - Cell reports, 2021 - cell.com
A recent study proposed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) hijacks the LINE-1 (L1) retrotransposition machinery to integrate into the DNA of infected …

Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2

TA Scott, A Supramaniam, A Idris, AA Cardoso… - … Therapy-Methods & …, 2022 - cell.com
SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused
significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of …

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

J Aguado, AA Amarilla, A Taherian Fard, EA Albornoz… - Nature aging, 2023 - nature.com
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …

Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

D Watterson, DK Wijesundara… - Clinical & …, 2021 - Wiley Online Library
Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational …

Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2

M Chhabra, CD Shanthamurthy… - Journal of Medicinal …, 2024 - ACS Publications
Herein, we report the synthesis and biological evaluation of a novel series of heparinoid
amphiphiles as inhibitors of heparanase and SARS-CoV-2. By employing a tailor-made …