Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Abstract Purpose of Review To briefly review epidemiology and pathophysiology of SICM
and provide a more extensive review of the data on diagnostic and management strategies …

Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

Background After a single-center trial and observational studies suggesting that early, goal-
directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials …

Background Early, goal-directed therapy (EGDT) is recommended in international
guidelines for the resuscitation of patients presenting with early septic shock. However …

Background The consensus definition of severe sepsis requires suspected or proven
infection, organ failure, and signs that meet two or more criteria for the systemic inflammatory …

Background: Sepsis is a global healthcare issue and continues to be the leading cause of
death from infection. Early recognition and diagnosis of sepsis is required to prevent the …

Background In a single-center study published more than a decade ago involving patients
presenting to the emergency department with severe sepsis and septic shock, mortality was …

Purpose To determine whether early goal-directed therapy (EGDT) reduces mortality
compared with other resuscitation strategies for patients presenting to the emergency …