Coenzyme A (CoA) is a ubiquitous essential cofactor that plays a central role in the
metabolism of carboxylic acids, including short-and long-chain fatty acids. In the last few …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

During embryogenesis, primordial germ cells (PGCs) have the potential to enter either
spermatogenesis or oogenesis. In a female genital ridge, or in a non-gonadal environment …

Despite 12 yr since the discovery of SRY, little is known at the molecular level about how
SRY and the SRY-related protein, SOX9 [SRY-related high-mobility group (HMG) box 9] …

Coenzyme A (CoA) is the predominant acyl carrier in mammalian cells and a cofactor that
plays a key role in energy and lipid metabolism. CoA and its thioesters (acyl-CoAs) regulate …

The primary event in mammalian sexual development is the differentiation of the bipotential
gonads into either testes or ovaries. Our understanding of the molecular pathways …

Pantetheinase (EC 3.5. 1.-) is an ubiquitous enzyme which in vitro has been shown to
recycle pantothenic acid (vitamin B5) and to produce cysteamine, a potent anti-oxidant. We …

Fetal exposure of male rats to di (n-butyl) phthalate (DBP) induces testicular changes
remarkably similar to testicular dysgenesis syndrome in humans; these include induction of …

Several host-adapted bacterial pathogens contain methyltransferases associated with type
III restriction-modification (RM) systems that are subject to reversible, high-frequency on/off …

Sex determination in mammals is controlled by the presence or absence of the Y-linked
gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) …