Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Molecular target inhibitors have been regularly approved by Food and Drug Administration
(FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

Background The introduction of targeted therapy for the treatment of BRAF-mutant
melanomas have improved survival rates in a significant proportion of patients. Nonetheless …

Background: Lenvatinib is in a first-line therapy for advanced hepatocellular carcinoma
(HCC). However, drug resistance is one of the principal obstacles for treatment failure. The …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

The clinical benefit of MAPK pathway inhibition in BRAF-mutant melanoma patients is
limited by the development of acquired resistance. Using drug-naïve cell lines derived from …

Simple Summary Uveal melanoma (UM) is a rare aggressive eye cancer. Although
treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of …

Background RNA-binding proteins (RBPs) play crucial and multifaceted roles in post-
transcriptional regulation. While RBPs dysregulation is involved in tumorigenesis and …

Highlights•Causal inference combines model and data to identify causations from
correlations.•Causality is indispensable for intervention, what if questions, and …