Oocyte developmental competence is the ability of the mature oocyte to be fertilized and
subsequently drive early embryo development. Developmental competence is acquired by …

Senescent cells secrete a combination of factors collectively known as the senescence-
associated secretory phenotype (SASP). The SASP reinforces senescence and activates an …

RNA-binding proteins are important modulators of mRNA stability, a crucial process that
determines the ultimate cellular levels of mRNAs and their encoded proteins. The …

Pervasive transcription of the human genome results in a heterogeneous mix of coding
RNAs and long noncoding RNAs (lncRNAs). Only a small fraction of lncRNAs have …

Variation in protein output across the genome is controlled at several levels, but the relative
contributions of different regulatory mechanisms remain poorly understood. Here, we …

Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

Background Alternative polyadenylation (APA) is emerging as a major post-transcriptional
mechanism for gene regulation, and dysregulation of APA contributes to several human …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

For a rapid induction and efficient resolution of the inflammatory response, gene expression
in cells of the immune system is tightly regulated at the transcriptional and post …

Background The sequence content of the 3′ UTRs of many mRNA transcripts is regulated
through alternative polyadenylation (APA). The study of this process using RNAseq data …