[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents

PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …

Benzothiazoles as potential antiviral agents

YI Asiri, A Alsayari, AB Muhsinah… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives The recent viral pandemic poses a unique challenge for healthcare providers.
Despite the remarkable progress, the number of novel antiviral agents in the pipeline is …

Potential antiviral options against SARS-CoV-2 infection

A Ianevski, R Yao, MH Fenstad, S Biza, E Zusinaite… - Viruses, 2020 - mdpi.com
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …

Antiviral agents from fungi: diversity, mechanisms and potential applications

R Linnakoski, D Reshamwala, P Veteli… - Frontiers in …, 2018 - frontiersin.org
Viral infections are amongst the most common diseases affecting people worldwide. New
viruses emerge all the time and presently we have limited number of vaccines and only few …

Identification and tracking of antiviral drug combinations

A Ianevski, R Yao, S Biza, E Zusinaite, A Männik, G Kivi… - Viruses, 2020 - mdpi.com
Combination therapies have become a standard for the treatment for HIV and hepatitis C
virus (HCV) infections. They are advantageous over monotherapies due to better efficacy …

Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine

PI Andersen, K Krpina, A Ianevski, N Shtaida, E Jo… - Viruses, 2019 - mdpi.com
Viruses are the major causes of acute and chronic infectious diseases in the world.
According to the World Health Organization, there is an urgent need for better control of viral …

Respiratory Barrier as a Safeguard and Regulator of Defense Against Influenza A Virus and Streptococcus pneumoniae

KS LeMessurier, M Tiwary, NP Morin… - Frontiers in …, 2020 - frontiersin.org
The primary function of the respiratory system of gas exchange renders it vulnerable to
environmental pathogens that circulate in the air. Physical and cellular barriers of the …

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

NV Ivanisenko, K Seyrek, NA Kolchanov… - Cell death …, 2020 - nature.com
The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-
2) poses a significant global public health threat. While urgent regulatory measures in …

Treating influenza infection, from now and into the future

S Davidson - Frontiers in immunology, 2018 - frontiersin.org
Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV
genome makes this virus incredibly successful, genetic drift allows for annual epidemics …

Synergistic interferon-alpha-based combinations for treatment of SARS-CoV-2 and other viral infections

A Ianevski, R Yao, E Zusinaite, LS Lello, S Wang, E Jo… - Viruses, 2021 - mdpi.com
Background: There is an urgent need for new antivirals with powerful therapeutic potential
and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons …