PURPOSE Despite the disproportionately high risk of breast cancer among women of
African heritage, little is known about the facilitators and barriers to implementing germline …

Black people have a higher incidence of colorectal cancer and worse survival rates when
compared with white people. Comprehensive genomic profiling was performed in 46,140 …

Background Pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) lead to increased risk of
breast, ovarian, and other cancers, but most variant-positive individuals in the general …

The BabySeq Project is a study funded by the National Institutes of Health and aimed at
exploring the medical, behavioral, and economic impacts of integrating genomic sequencing …

Abstract Background: Sub-Saharan Africa (SSA) has a high proportion of premenopausal
hormone receptor negative breast cancer. Previous studies reported a strikingly high …

Inequities in preventive cancer screening, diagnosis, treatment, and inferior cancer
outcomes continue to pose challenges across the cancer continuum. While the exact …

Evidence shows that Black women diagnosed with breast cancer are substantially less likely
to undergo BRCA testing and other multipanel genetic testing compared to White women …

Delineating functionally normal variants from functionally abnormal variants in tumor
suppressor proteins is critical for cancer surveillance, prognosis, and treatment options …

In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-
naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to …

The prevalence and contribution of BRCA1/2 (BRCA) pathogenic variants (PVs) to the
cancer burden in Latin America are not well understood. This study aims to address this …